Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA
Brett J. Hos, Elena Tondini, Marcel Camps, Wesley Rademaker, Jitske van den Bulk, Dina Ruano, George M. C. Janssen, Arnoud H. de Ru, Peter J. van den Elsen, Noel F.C.C. de Miranda, Peter A. van Veelen, Ferry Ossendorp
Abstract
T cell responses, which helped tumor control in vivo. Thus, this CIITA transfection approach aids to identify relevant T helper epitopes presented by any MHC class II allele that would be otherwise very difficult to predict and reveals important targets for cancer immunotherapy.
Topics & Concepts
CIITARegulatorMaster regulatorBiologyEpitopeMHC class IMHC class IIMajor histocompatibility complexGeneticsImmune systemAntigenGeneTranscription factorImmunotherapy and Immune ResponsesImmune Cell Function and InteractionT-cell and B-cell Immunology