Visible Light-Mediated Carbamoylation of <i>para</i>-Quinone Methides
Tavinder Singh, Ganesh Chandra Upreti, Shivani Arora, Himanshu Chauhan, Anand Singh
Abstract
We report a photocatalytic approach for the installation of the amide moiety onto para -quinone methides. This transformation features a net reductive approach for the generation of carbamoyl radicals from amide-substituted Hantzsch ester derivatives under transition metal-free conditions. This protocol exhibits wide scope and allows access to diarylacetamides employing a C–C bond formation approach.
Topics & Concepts
QuinoneChemistryBusinessStereochemistrySynthesis of Indole DerivativesChemical Synthesis and ReactionsSulfur-Based Synthesis Techniques