Palladium-Catalyzed Intramolecular Heck/Aminocarbonylation of Alkene-Tethered Iodobenzenes with Nitro Compounds: Synthesis of Carbamoyl-Substituted Benzoheterocycles
Yun Chan Kang, Jin‐Liang Lu, Zhi Zhang, Ying‐Kang Liang, Ai‐Jun Ma, Jin‐Bao Peng
Abstract
A palladium-catalyzed intramolecular Heck/aminocarbonylation of alkene-tethered iodobenzenes with nitro compounds has been developed for the synthesis of carbamoyl-substituted benzoheterocycles. Using Mo(CO)6 as a solid CO source, no external reductant or additives were needed in this procedure. Both nitroarenes and nitroalkanes were well tolerated. A range of carbamoyl-substituted dihydrobenzofurans and indolines were prepared in moderate to high yields.
Topics & Concepts
ChemistryAlkeneIntramolecular forceNitroPalladiumCatalysisHeck reactionCarbonylationMedicinal chemistryOrganic chemistryCombinatorial chemistryCarbon monoxideAlkylCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsNanomaterials for catalytic reactions