Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer cell lines
Marian W. Aziz, Aliaa M. Kamal, Khaled O. Mohamed, Adel A. El‐Gendy
Topics & Concepts
QuinazolinoneChemistryPharmacophoreErlotinibCytotoxicityCytotoxic T cellAcetamideEGFR inhibitorsCell cultureQuantitative structure–activity relationshipPharmacologyStereochemistryEpidermal growth factor receptorBiochemistryIn vitroReceptorOrganic chemistryGeneticsMedicineBiologyQuinazolinone synthesis and applicationsCancer therapeutics and mechanismsSynthesis and biological activity