Structurally diverse diterpenoid alkaloids from the lateral roots of <i>Aconitum carmichaelii</i> Debx. and their anti-tumor activities based on <i>in vitro</i> systematic evaluation and network pharmacology analysis
Yang Yu, Shifei Wu, Jianqing Zhang, Jiayuan Li, Changliang Yao, Wenyong Wu, Yingying Wang, Hongjian Ji, Wenlong Wei, Min Gao, Yun Li, Shuai Yao, Yong Huang, Qirui Bi, Hua Qu, De‐an Guo
Abstract
-DA skeleton. In addition, all of the isolated DAs, with chemical structures confirmed, were further applied for network pharmacology analysis, in order to give an insight into the possible mechanisms of their anti-tumor activities. As a result, 173 potential targets and three most important pathways related to non-small-cell lung carcinoma were finally unearthed.
Topics & Concepts
RanunculaceaeAconitumTerpenoidTraditional medicineIn vitroStereochemistryChemistryBiologyMedicineAlkaloidBotanyBiochemistryPlant-based Medicinal ResearchBioactive Natural Diterpenoids ResearchBerberine and alkaloids research