Identification of a Linear B Cell Epitope on p54 of African Swine Fever Virus Using Nanobodies as a Novel Tool
Huijun Zhao, Gaijie Wang, Haoxin Dong, Shuya Wu, Yongkun Du, Bo Wan, Pengchao Ji, Yanan Wu, Dawei Jiang, Guoqing Zhuang, Hong Duan, Gaiping Zhang, Angke Zhang
Abstract
, among different ASFV strains, and it can induce humoral immune responses in pigs. This is the first report using virus-specific nanobodies as a tool to identify some special epitopes that cannot be recognized by conventional monoclonal antibodies. This study opens up nanobodies as a new tool for identifying epitopes and also provides a theoretical basis for understanding p54-induced neutralizing antibodies.
Topics & Concepts
EpitopeVirologyIdentification (biology)VirusComputational biologyBiologyClassical swine feverAntibodyImmunologyBotanyAnimal Disease Management and EpidemiologyVector-Borne Animal DiseasesViral gastroenteritis research and epidemiology