TGFBR3L is an inhibin B co-receptor that regulates female fertility
Emilie Brûlé, Ying Wang, Yining Li, Yeu‐Farn Lin, Xiang Zhou, Luisina Ongaro, Carlos Agustín Isidro Alonso, Evan R. S. Buddle, Alan L. Schneyer, Chang‐Hyeock Byeon, Cynthia S. Hinck, Natalia Mendelev, John P. Russell, Mitra Cowan, Ulrich Boehm, Frederique Ruf-Zamojski, Michel Zamojski, Cynthia L. Andoniadou, Stuart C. Sealfon, Craig A. Harrison, Kelly L. Walton, Andrew P. Hinck, Daniel J. Bernard
Abstract
knockout mice exhibit increased FSH levels, ovarian follicle development, and litter sizes. In contrast, female mice lacking both TGFBR3L and betaglycan are infertile. TGFBR3L’s function and cell-specific expression make it an attractive new target for the regulation of FSH and fertility.
Topics & Concepts
FertilityReceptorBiologyEndocrinologyInternal medicineMedicineGeneticsEnvironmental healthPopulationTGF-β signaling in diseasesReproductive Biology and FertilityKruppel-like factors research