Discovery of phenyl-linked symmetric small molecules as inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction
Yizhe Wu, Yu Zhang, Yu Guo, Zhichao Pan, Shichun Zhong, Xinxin Jin, Weihao Zhuang, Sikang Chen, Jian Gao, Wenhai Huang, Xiaowu Dong, Jinxin Che
Topics & Concepts
ChemistryLinkerSmall moleculeDocking (animal)Programmed cell deathLigand (biochemistry)StereochemistryIC50ArylCombinatorial chemistryIn vitroReceptorApoptosisBiochemistryMedicineOrganic chemistryOperating systemAlkylNursingComputer scienceCancer Immunotherapy and BiomarkersCAR-T cell therapy researchPeptidase Inhibition and Analysis