A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis
Frances V Hundley, Nerea Sanvisens Delgado, Harold Marin, Kaili L. Carr, Ruilin Tian, David P. Toczyski
Topics & Concepts
BiologyCRISPRUbiquitinMitosisCas9GeneticsDNA repairProteasomeGenePhenotypeUbiquitin-Protein LigasesCell biologyComputational biologyUbiquitin ligaseUbiquitin and proteasome pathwaysProtein Degradation and InhibitorsAutophagy in Disease and Therapy