Immunomodulation by Mosquito Salivary Protein AgSAP Contributes to Early Host Infection by <i>Plasmodium</i>
Gunjan Arora, Andaleeb Sajid, Yu-Min Chuang, Yuemei Dong, Akash Gupta, Kristen Gambardella, Kathleen DePonte, Lionel Almeras, George Dimopolous, Erol Fikrig
Abstract
infection in the vertebrate host. Individuals living in countries where malaria is endemic generate antibodies against AgSAP, which indicates that AgSAP can serve as a biomarker for disease prevalence and epidemiological analysis.
Topics & Concepts
Plasmodium bergheiAnopheles gambiaeBiologyMalariaPlasmodium falciparumSalivaPlasmodium (life cycle)VirologyAnophelesImmunologyPlasmodium yoeliiAnopheles stephensiCircumsporozoite proteinAntigenImmune systemPlasmodium gallinaceumMicrobiologyMalaria vaccineHost (biology)Cell biologyParasite hostingPathogenIn silicoImmunizationSalivary glandApicomplexaInvertebrate Immune Response MechanismsAntimicrobial Peptides and ActivitiesNeurobiology and Insect Physiology Research