Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
Wuchang Zhang, Wei Liu, Lingfei Jia, Demeng Chen, Insoon Chang, Michael P. Lake, Laurent A. Bentolila, Cun‐Yu Wang
Topics & Concepts
BiologyCell biologyHeterochromatin protein 1DemethylaseCancer researchEukaryotic DNA replicationHistoneCell cycleDNA replicationHeterochromatinCellDNAChromatinGeneticsCancer Immunotherapy and BiomarkersEpigenetics and DNA MethylationImmune cells in cancer