Development of small-molecule BRD4 degraders based on pyrrolopyridone derivative
Jian Zhang, Pan Chen, Peiyu Zhu, Peiyuan Zheng, Tao Wang, Lixun Wang, Changliang Xu, Jinpei Zhou, Huibin Zhang
Topics & Concepts
BRD4ChemistryEpigeneticsSmall moleculeBromodomainProteolysisCell cycle checkpointCell biologyCell growthCell cycleCancer researchBiochemistryApoptosisGeneBiologyEnzymeProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways