Enantioselective synthesis of axially chiral carbamates and amides with carbon dioxide <i>via</i> copper catalysis
Bangxiong Kang, Lu Wang, Xihu Sun, Hongjian Liu, Zhonglin Wen, Yanwei Ren, Chaorong Qi, Huanfeng Jiang
Abstract
Enantioselective synthesis of axially chiral carbamates and amides was achieved via copper-catalyzed coupling of cyclic diaryliodonium salts with CO 2 and amines. This method features mild conditions, broad substrate scope and excellent enantioselectivity.
Topics & Concepts
ChemistryEnantioselective synthesisCopperCatalysisSubstrate (aquarium)Axial symmetryCombinatorial chemistryCarbon dioxideOrganic chemistryStructural engineeringOceanographyGeologyEngineeringCarbon dioxide utilization in catalysisAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis