The effect of size and surface ligands of iron oxide nanoparticles on blood compatibility
Tao Liu, Ru Bai, Huige Zhou, Rongqi Wang, Jing Liu, Yuliang Zhao, Chunying Chen
Abstract
. Compared with polyacrylic acid-modified SPIONs, hyaluronic acid- and chitosan-modified SPIONs least affected red blood cells, platelets, coagulation, and complement activation. Hence, hyaluronic acid- and chitosan-coated SPIONs are more suitable for nanomedicine applications than polyacrylic acid-coated SPIONs. Furthermore, the interaction between SPIONs and blood components strongly correlated with the administered concentration of nanoparticles. These results will provide some experimental information for safe-by-design SPIONs.
Topics & Concepts
Compatibility (geochemistry)NanoparticleIron oxideOxideChemistryChemical engineeringMaterials scienceNanotechnologyMetallurgyEngineeringNanoparticle-Based Drug DeliveryNanoparticles: synthesis and applicationsElectrohydrodynamics and Fluid Dynamics