Early pulmonary function and mid‐term outcome in lung transplantation after<i>ex‐vivo</i>lung perfusion – a single‐center, retrospective, observational, cohort study
Jacopo Fumagalli, Lorenzo Rosso, F. Gori, Letizia Corinna Morlacchi, V. Rossetti, Paolo Tarsia, Francesco Blasi, I. Righi, Paolo Mendogni, A. Palleschi, Davide Tosi, Gianluca Bonitta, Mario Nosotti, E. Benazzi, Vittorio Scaravilli, Franco Valenza, Giacomo Grasselli, Alberto Zanella
Abstract
[276 (206; 374) vs. 204 (133; 245) mmHg, P < 0.05], more frequent extracorporeal support (18% vs. 32%, P = 0.053) and longer mechanical ventilation duration [28 days of ventilator-free days: 27 (24; 28) vs. 26 (19; 27), P < 0.05]. ICU length of stay [4 (2; 9) vs. 6 (3; 12) days, P = 0.208], 28-day survival (99% vs. 97%, P = 0.735), and 1-year respiratory function were similar between groups. Log-rank analysis (median follow-up 2.5 years) demonstrated similar patients' survival (P = 0.439) and time free of chronic lung allograft disease (P = 0.484). The EVLP program increased by 16% the number of LuTX. Compared to standard donors, EVLP patients had worse respiratory function immediately after LuTX but similar early and mid-term outcomes.