A directing group-assisted ruthenium-catalyzed approach to access <i>meta</i>-nitrated phenols
Sheuli Sasmal, Soumya Kumar Sinha, Goutam Kumar Lahiri, Debabrata Maiti
Abstract
<italic>meta</italic>-Selective C–H nitration of phenol derivatives was developed using a Ru-catalyzed σ-activation strategy. Cu(NO<sub>3</sub>)<sub>2</sub>·3H<sub>2</sub>O was employed as the nitrating source, whereas Ru<sub>3</sub>(CO)<sub>12</sub> was found to be the most suitable metal catalyst for the protocol.
Topics & Concepts
RutheniumCatalysisPhenolNitrationPhenolsGroup (periodic table)ChemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Cross-Coupling Reactions