Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their <i>C</i><sub>1</sub>-symmetrical mono-ligated titanium(<scp>iv</scp>) complexes as highly stable highly active antitumor compounds
Gilad Nahari, Edit Y. Tshuva
Abstract
Substituting differently the two aromatic rings of bis(phenolato)-bis(alkoxo) ligands yields <italic>C</italic><sub>1</sub>-symmetrical titanium(<sc>iv</sc>) complexes that are highly soluble and stable in biological media and display marked cytotoxicity toward various cancer cells.
Topics & Concepts
TitaniumChemistryBisphenol ACytotoxicityStereochemistryMedicinal chemistryCombinatorial chemistryNuclear chemistryOrganic chemistryIn vitroBiochemistryEpoxyMetal complexes synthesis and propertiesOrganometallic Complex Synthesis and CatalysisFerrocene Chemistry and Applications