Ru<sup>(II)</sup>-catalyzed P<sup>(III)</sup>-assisted C8-alkylation of naphthphosphines
Wentao Ma, Mao‐Gui Huang, Yueliuting Fu, Zhonghui Wang, Jun-Yang Tao, Jiawei Li, Yue‐Jin Liu, Ming‐Hua Zeng
Abstract
We report a phosphine-directed ruthenium-catalyzed C8-selective alkylation of naphthalenes with alkenes. This protocol provides straightforward access to a large library of electron-rich C8-alkyl substituent 1-naphthphosphines, which outperformed common commercial phosphines and their precursors in the Pd-catalyzed Suzuki-Miyaura coupling of aryl bromides with alkylboronic acid.
Topics & Concepts
AlkylationCatalysisChemistryMedicinal chemistryRadiochemistryOrganic chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis