Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS
Yuta Adachi, Ryo Kimura, Kentaro Hirade, Shogo Yanase, Yuki Nishioka, Natsumi Kasuga, Rui Yamaguchi, Hiromichi Ebi
Topics & Concepts
KRASMRASMAPK/ERK pathwayCancer researchBiologyCell biologySignal transductionCancerGeneticsColorectal cancerVoltagePhysicsVector controlInduction motorQuantum mechanicsHippo pathway signaling and YAP/TAZCellular Mechanics and InteractionsWnt/β-catenin signaling in development and cancer