Mechanisms and Consequences of Newcastle Disease Virus W Protein Subcellular Localization in the Nucleus or Mitochondria
Yanling Yang, Jia Xue, Qingyuan Teng, Li Xiao, Yawen Bu, Guozhong Zhang
Abstract
In contrast, very little is known about the function of NDV W protein, and this limited information is based on studies of the Nipah virus W protein. Here, we investigated the localization mechanism of NDV W protein and its subcellular distribution in mitochondria. We found that W protein localization differences impact IFN-β production, consequently affecting NDV virulence, replication, and pathogenicity. This work provides new insights on the differential localization mechanism of NDV W proteins, along with fundamental knowledge for understanding the functions of W proteins in NDV and other paramyxoviruses.
Topics & Concepts
BiologyCytoplasmNuclear localization sequenceSubcellular localizationNuclear export signalCell biologyCell nucleusNuclear proteinVirusViral replicationNucleusMolecular biologyVirologyGeneticsGeneTranscription factorVirology and Viral DiseasesViral Infections and VectorsAnimal Virus Infections Studies