Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid: evidence of their ability to cross the BBB
Mélanie Le Sayec, Diogo Carregosa, Khadija Khalifa, Chiara de Lucia, Dag Aarsland, Cláudia Nunes dos Santos, Ana Rodriguez‐Mateos
Abstract
We investigated the presence of (poly)phenol and methylxanthine metabolites in plasma and cerebrospinal fluid from individuals at risk of dementia suing LC-MS and predicted their mechanism of transport across the BBB using in silico modelling.
Topics & Concepts
Cerebrospinal fluidNeuroprotectionChemistryIn silicoPharmacologyBlood–brain barrierPhenolsMetaboliteBioavailabilityBiochemistryChromatographyCentral nervous systemBiologyEndocrinologyNeuroscienceGeneMetabolomics and Mass Spectrometry StudiesAdvanced Chemical Sensor TechnologiesBiochemical Analysis and Sensing Techniques