Bioactivity-guided isolation of the major anthocyanin from<i>Lycium ruthenicum</i>Murr. fruit and its antioxidant activity and neuroprotective effects<i>in vitro</i>and<i>in vivo</i>
Shasha Chen, Na Hu, Honglun Wang, Yongning Wu, Guoliang Li
Abstract
-carboxymethyllysine (CML)-treated Neuro-2a cells by enhancing cell viability in a dose-dependent manner. CML-induced apoptosis was also reduced by Pn3G5G potentially by suppressing oxidative stress and inflammation. More importantly, Pn3G5G significantly improved cognitive impairment, neuroinflammation and neuronal apoptosis in D-galactose-induced aging mice. The result suggests the development of Pn3G5G as a healthcare product or a potent dietary supplement with antioxidant and neuroprotective effects.
Topics & Concepts
NeuroprotectionIn vitroIn vivoAntioxidantOxidative stressApoptosisAnthocyaninPharmacologyBiologyTraditional medicineChemistryBiochemistryBotanyMedicineBiotechnologyAntioxidants, Aging, Portulaca oleraceaPolysaccharides and Plant Cell WallsMedicinal Plants and Bioactive Compounds