Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature
Trương Thanh Tùng, John Nielsen
Abstract
O conditions at room temperature without the addition of tertiary amine bases. The water-soluble coupling reagent EDC·HCl is a key component in the reaction. The reaction runs smoothly with unsubstituted/substituted ammonium salts and provides a clean product without column chromatography. Our reaction tolerates both carboxylate (which are unstable in other forms) and amine salts (which are unstable/volatile when present in free form). We believe that the reported method could be used as an alternative and suitable method at the laboratory and industrial scales.
Topics & Concepts
CarboxylateAmmoniumAqueous solutionChemistryAmideMetalCoupling (piping)Polymer chemistryInorganic chemistrySalt (chemistry)Organic chemistryMaterials scienceMetallurgyChemical Synthesis and AnalysisChemical Synthesis and ReactionsAsymmetric Synthesis and Catalysis