Cerium-Encapsulated Sb<sup>III</sup>–Se<sup>IV</sup>-Templating Polyoxotungstate for Electrochemically Sensing Human Multidrug Resistance Gene Segment
Xiaodan Jia, Zhigang Tang, Lina Meng, Zixu Wang, Dan Wang, Lijuan Chen, Junwei Zhao
Abstract
A tower-like Sb III –Se IV -templating polyoxotungstate [H 2 N(CH 3 ) 2 ] 12 Na 7 H 3 [Ce 0.5 /Na 0.5 (H 2 O) 5 ] 2 [SbSe 2 W 21 O 75 ] 2 ·50H 2 O ( 1 ) was synthesized, whose skeleton is assembled from two prolonged lacunary Dawson [SbSe 2 W 21 O 75 ] 13– units and two [Ce 0.5 /Na 0.5 (H 2 O) 5 ] 2+ linkers. The uncommon [SbSe 2 W 21 O 75 ] 13– unit can be viewed as a combination of one [SeW 6 O 21 ] 2– group grafted onto a trivacant Dawson [SbSeW 15 O 54 ] 11– subunit. The conductive composite 1 -Au@rGO containing 1, gold nanoparticles, and reduced graphene oxide (rGO) was conveniently prepared, using which the 1 -Au@rGO-based electrochemical genosensor was constructed for detecting human multidrug resistance gene segment. This work enriches structural types of dual-heteroatom-inserted polyoxometalates and promotes the application of polyoxometalates in genosensors.