NOX2 deficiency enhances priming and activation of the NLRP3 inflammasome
Blandine Monjarret, Sara Shour, Daniela Stanga, Aissa Benyoucef, Émilie Heckel, Lorie Marchitto, Jennifer W. Leiding, Guilhem Cros, Isabel Fernández, Jean‐Sébastien Joyal, Fabien Touzot
Topics & Concepts
InflammasomeChronic granulomatous diseasePyroptosisNADPH oxidasePyrin domainCaspase 1Cell biologyNOD2AIM2ChemistryImmunologyBiologyInflammationInnate immune systemImmune systemReactive oxygen speciesNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammasome and immune disordersinterferon and immune responses