SRC-2 Coactivator: a role in human metabolic evolution and disease
Bert W. O’Malley
Abstract
The large family of transcriptional coactivators originated with the cloning of the subfamily of Steroid Receptor Coactivators (SRC-1,2,3). These 3 coactivators serve as primary 'master genes' to direct the coordinate transcription of multiple genes required for physiological goals in cells, specifically, carbohydrate, lipid, or anabolic growth metabolisms. SRC-2 is of special interest in terms of lipid metabolism and energy accrual and is the topic of a collection of our research discoveries and publications described in this Perspective.
Topics & Concepts
CoactivatorNuclear receptor coactivator 2Nuclear receptor coactivator 3BiologySubfamilyHuman geneticsGeneNuclear receptorProto-oncogene tyrosine-protein kinase SrcLipid metabolismTranscription factorGeneticsBioinformaticsReceptorEndocrinologyEstrogen and related hormone effectsHormonal Regulation and HypertensionAdipose Tissue and Metabolism