New bis([1,2,4]triazolo)[4,3-a:3′,4′-c]quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, in silico studies, and anticancer evaluation
Mohammed M. Alanazi, Hazem A. Mahdy, Nawaf A. Alsaif, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Sultan M. Alsubaie, Mohammed A. Dahab, Ibrahim H. Eissa
Topics & Concepts
ChemistryIn silicoSorafenibApoptosisQuinoxalineCytotoxic T cellDocking (animal)Cell cultureCytotoxicityCell cycleCaspase 3IC50StereochemistryLead compoundCell growthIn vitroBiochemistryProgrammed cell deathCancer researchBiologyNursingGeneticsHepatocellular carcinomaGeneOrganic chemistryMedicineSynthesis and Biological EvaluationSynthesis and biological activityQuinazolinone synthesis and applications