Visible-Light-Induced Regio- and Stereoselective C(sp<sup>2</sup>)–H Trifluoroethylation of Enamides with 2,2,2-Trifluoroethyl Iodide
Kai Zhao, Zeyu Zhang, Xianlu Cui, Ying-Xue Wang, Xian-Dan Wu, Weiming Li, Jia-Xu Wu, Lili Zhao, Jingyu Guo, Teck‐Peng Loh
Abstract
A photoredox-catalyzed regio- and stereoselective trifluoroethylation reaction of enamides using commercially available 2,2,2-trifluoroethyl iodide as trifluoroethylating agents has been developed, furnishing geometrically defined and synthetically and physiochemically pivotal β-trifluoroethylated enamides bearing a diverse range of functional groups.
Topics & Concepts
StereoselectivityChemistryIodideCombinatorial chemistryStereochemistryCatalysisOrganic chemistryFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsRadical Photochemical Reactions