New chromone analog and pyrrole alkaloid produced by <i>Penicillium sclerotiorum</i> and their antibacterial activity
Liangxiu Liao, Ze‐Diao Huang, Fu-Ting Wei, Wenjing Wang, Xiao‐Long Yang
Abstract
A new chromone analog (1) and a new pyrrole alkaloid (2), together with four known compounds, were isolated from the endophytic fungus Penicillium sclerotiorum MPT-250 obtained from the stems of Taxus wallichiana var. chinensis (Pilger) Florin. The structural elucidation of these metabolites was performed by high-resolution mass spectrometry and NMR spectroscopy. Compounds 1 and 5 exhibited significant antibacterial activity against carbapenems-resistant Pseudomonas aeruginosa and multidrug-resistant Enterococcus faecium with an minimum inhibitory concentration (MIC) value of 3.13 μg/ml respectively.
Topics & Concepts
ChromoneAlkaloidStereochemistryChemistryPenicilliumMinimum inhibitory concentrationAntibacterial activityOrganic chemistryBiologyBacteriaAntimicrobialFood scienceGeneticsMicrobial Natural Products and BiosynthesisFungal Biology and ApplicationsMicrobial Metabolism and Applications