Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy
Bo Kong, Zhaohong Zhu, Hongmei Li, Qianqian Hong, Cong Wang, Yu Ma, Wan Zheng, Fei Jiang, Zhimin Zhang, Ting Ran, Yuanyuan Bian, Na Yang, Tao Lu, Jiapeng Zhu, Weifang Tang, Yadong Chen
Topics & Concepts
BromodomainChemistryBRD4BET inhibitorEpigeneticsCell cycle checkpointCell cycleSmall moleculeApoptosisHistoneBiochemistryStereochemistryCancer researchBiologyGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsHistone Deacetylase Inhibitors Research