Comparative Genomics of Borderline Oxacillin-Resistant Staphylococcus aureus Detected during a Pseudo-outbreak of Methicillin-Resistant S. aureus in a Neonatal Intensive Care Unit
Sanjam S. Sawhney, Eric M. Ransom, Meghan A. Wallace, Patrick Reich, Gautam Dantas, Carey‐Ann D. Burnham
Abstract
In this study, we found a high prevalence of Staphylococcus aureus isolates exhibiting a borderline oxacillin resistance phenotype (BORSA) in our neonatal intensive care unit (NICU) serendipitously due to the type of MRSA screening agar used by our laboratory for active surveillance cultures. Subsequent phenotypic and molecular characterization highlighted an unexpected prevalence and variability of BORSA isolates.
Topics & Concepts
CefoxitinStaphylococcus aureusSCCmecMicrobiologyMethicillin-resistant Staphylococcus aureusBroth microdilutionMedicineOutbreakBiologyAntimicrobialVirologyMinimum inhibitory concentrationBacteriaGeneticsAntimicrobial Resistance in StaphylococcusBacterial Identification and Susceptibility TestingInfective Endocarditis Diagnosis and Management