Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus
Daniela Antunes, Samuel M. Gonçalves, Vasiliki Matzaraki, Cláudia S. Rodrigues, Relber Aguiar Gonçales, Joana Rocha, Jorge Sáiz, António Marques, Egídio Torrado, Ricardo Silvestre, Fernando Rodrigues, Frank L. van de Veerdonk, Coral Barbas, Mihai G. Netea, Vinod Kumar, Cristina Cunha, Agostinho Carvalho
Abstract
models of infection, and genetic variants in human glutamine metabolism genes regulated cytokine production in response to fungal stimulation. This work highlights the relevance of glutaminolysis to the pathogenesis of aspergillosis and supports a role for interindividual genetic variation influencing glutamine metabolism in susceptibility to infection.
Topics & Concepts
Aspergillus fumigatusImmune systemReprogrammingBiologyMicrobiologyAspergillosisInnate immune systemGlutaminePathogenFungal pathogenImmunologyAspergillusCellBiochemistryAmino acidImmune responses and vaccinationsImmunotherapy and Immune ResponsesCancer Research and Treatments