NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice
Annadurai Anandhan, Nhat Nguyen, Arjun Syal, Luke A Dreher, Matthew Dodson, Donna D Zhang, Lalitha Madhavan
Abstract
mice showed significantly amplified oxidative stress, greater expression of inflammatory markers, and signs of increased autophagic burden, especially in the midbrain, striatum and cortical brain regions. These results support an important role for NRF2, early in PD progression. More broadly, it indicates NRF2 biology as fundamental to PD pathogenesis and suggests that targeting NRF2 activation may delay the onset and progression of PD.
Topics & Concepts
Substantia nigraOxidative stressAlpha-synucleinDopaminergicAutophagyPhosphorylationBiologyKnockout mouseNeuropathologyCell biologyDopamineContext (archaeology)Gene knockinParkinson's diseaseGenetically modified mouseNeuroscienceTransgeneEndocrinologyInternal medicineMedicineDiseaseBiochemistryGenePaleontologyApoptosisParkinson's Disease Mechanisms and TreatmentsGenomics, phytochemicals, and oxidative stress