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Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

Michael D. Crowther, Garry Dolton, Mateusz Legut, Marine E. Caillaud, Angharad Lloyd, Meriem Attaf, Sarah A. E. Galloway, Cristina Rius, Colin Farrell, Barbara Szomolay, Ann Ager, Alan L. Parker, Anna Fuller, Marco Donia, James McCluskey, Jamie Rossjohn, Inge Marie Svane, John D. Phillips, Andrew K. Sewell

2020Nature Immunology263 citationsDOIOpen Access PDF

Topics & Concepts

CRISPRMHC class IBiologyGenomeGeneticsComputational biologyGenome editingCas9Major histocompatibility complexGeneCRISPR and Genetic EngineeringCAR-T cell therapy researchImmune Cell Function and Interaction
Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1 | Litcius