Binding motif of ebselen in solution: chalcogen and hydrogen bonds team up
Andrea Daolio, Patrick Scilabra, Maria Enrica Di Pietro, Chiara Resnati, Kari Rissanen, Giuseppe Resnati
Abstract
Ebselen, a compound active against SARS-CoV-2, forms a bifurcated supramolecular synthon thanks to chalcogen bond and hydrogen bond cooperation.
Topics & Concepts
ChemistrySynthonChalcogenEbselenHydrogen bondSupramolecular chemistryStereochemistryCrystallographyCrystal structureOrganic chemistryMoleculeEnzymeGlutathione peroxidaseGlutathioneOrganoselenium and organotellurium chemistryOrganometallic Compounds Synthesis and CharacterizationCrystal structures of chemical compounds