Novel halogenated arylvinyl-1,2,4 trioxanes as potent antiplasmodial as well as anticancer agents: Synthesis, bioevaluation, structure-activity relationship and in-silico studies
Mohit K. Tiwari, Paolo Coghi, Prakhar Agrawal, Dharmendra Kumar Yadav, Li Yang, Qiu Congling, Dinkar Sahal, Vincent Kam Wai Wong, Sandeep Chaudhary
Topics & Concepts
ChemistryArtemisininPlasmodium falciparumIC50In vitroIn vivoStereochemistryIn silicoArtesunateCell cultureCytotoxicityLead compoundStructure–activity relationshipPharmacologyBiochemistryMalariaBiologyGeneGeneticsBiotechnologyImmunologySynthesis and Catalytic ReactionsSynthesis and biological activityMalaria Research and Control