8-Hydroxyquinoline-modified ruthenium(<scp>ii</scp>) polypyridyl complexes for JMJD inhibition and photodynamic antitumor therapy
Xiu-Rong Ma, Junjian Lu, Peixin Yang, Zheng Zhang, Bo Huang, Rong‐Tao Li, Rui‐Rong Ye
Abstract
of JMJD, resulting in the upregulation of histone-methylation levels in human lung cancer (A549) cells, and the upregulation was more pronounced under light conditions. In addition, MTT data showed that Ru1 and Ru2 exhibited lower dark toxicity, and light irradiation could significantly enhance their antitumor activity. The marked photodynamic activities of Ru1 and Ru2 could induce the elevation of reactive oxygen species (ROS), depolarization of mitochondrial membrane potential (MMP), and activation of caspases. These mechanistic studies indicated that Ru1 and Ru2 could induce apoptosis through the combination of JMJD inhibitory and PDT activities, thereby achieving dual antitumor effects.