Initial Hepatitis C Virus Infection of Adult Hepatocytes Triggers a Temporally Structured Transcriptional Program Containing Diverse Pro- and Antiviral Elements
Birthe Tegtmeyer, Gabrielle Vièyres, Daniel Tödt, Chris Lauber, Corinne Ginkel, Michael Engelmann, Maike Herrmann, Christian K. Pfaller, Florian W. R. Vondran, Ruth Broering, Ehsan Vafadarnejad, Antoine‐Emmanuel Saliba, Christina Puff, Wolfgang Baumgärtner, Csaba Miskey, Zoltán Ivics, Eike Steinmann, Thomas Pietschmann, Richard J. P. Brown
Abstract
combined with infection-induced upregulation of IFN-mediated effector genes suppresses virus propagation. On the other, we detect transcriptional signatures of host translational inhibition, which likely reduces processing of IFN-regulated gene transcripts and facilitates virus survival. Together, our data provide important insights into constitutive and virus-induced transcriptional programs in PHHs, and identifies simultaneous antagonistic dysregulation of pro-and anti-viral programs which may facilitate host tolerance and promote viral persistence.