<i>INSR</i> and <i>ISR‑1</i> gene polymorphisms and the susceptibility of essential hypertension: A meta‑analysis

Abstract

<em>INSR</em> and <em>ISR‑1</em> may be candidate genes for essential hypertension (EH). However, the genetic association between the <em>INSR</em> and <em>ISR‑1</em> gene polymorphisms and EH risk remains contradictory. To determine a more precise association of the <em>INSR</em> and <em>ISR‑1</em> gene polymorphisms and EH, the present study performed a meta‑analysis. Eligible studies up to Jan 2021 were retrieved from multiple databases including PubMed, Embase, Web of Science and China National Knowledge Infrastructure. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the genetic associations between the allele, dominant and recessive models of <em>INSR</em> Nsil, RsaI and <em>ISR‑1</em> G972R polymorphisms and EH susceptibility. A total of 10 case‑control studies encompassing 2,782 subjects including 1,289 cases and 1,493 controls were evaluated for the present meta‑analysis. Neither of the allele, dominant and recessive models of <em>INSR</em> Nsil and <em>ISR‑1</em> G972R polymorphisms was associated with EH risk (P&gt;0.05). While the allele [P=0.0008, OR=0.58, (95% CI)=(0.42, 0.80)], dominant [P=0.02, OR=0.59, (95% CI)=(0.38, 0.92)] and recessive models [P=0.003, OR=0.38, (95% CI)=(0.20, 0.72)] of <em>INSR</em> Rsal polymorphism were associated with decreased risk of EH. Subgroup analysis according to ethnicity showed that the significant associations between the allele, dominant and recessive models of <em>INSR</em> Rsal polymorphism and EH risk were observed in Caucasian populations, but not in Asian populations (P&gt;0.05). In conclusion, the <em>INSR</em> Rsal polymorphism is probably a protective factor for EH. To identify the result, additional case‑control designed research with larger numbers of subjects are required.

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