Ex vivo aortic stiffness in mice with different eNOS activity
Arthur Leloup, Cor E. Van Hove, Sofie De Moudt, Gilles W. De Keulenaer, Paul Fransen
Abstract
Endothelial function and NO bioavailability are important determinants of aortic biomechanics and function. With a new technique we investigated the ex vivo aortic segment biomechanics of different mouse models with altered NO signaling. Our experiments clearly show that chronic distortion of NO signaling triggered several compensatory mechanisms that reflect the organism's attempt to maintain optimal central hemodynamics.
Topics & Concepts
Ex vivoBiomechanicsHemodynamicsIn vivoEnosMedicineBiologyInternal medicineAnatomyNitric oxideBiotechnologyNitric oxide synthaseNitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionATP Synthase and ATPases Research