Mitochondrial Ca2+-overloading by oxygen/glutathione depletion-boosted photodynamic therapy based on a CaCO3 nanoplatform for tumor synergistic therapy
Jiawei Zhu, Aihong Jiao, Qinzhe Li, Xinyi Lv, Xiaorui Wang, Xuejiao Song, Buhong Li, Yewei Zhang, Xiaochen Dong
Topics & Concepts
Photodynamic therapyTumor microenvironmentReactive oxygen speciesMitochondrionButhionine sulfoximineGlutathioneCatalaseApoptosisChemistryMitochondrial ROSCancer cellProgrammed cell deathTumor hypoxiaBiochemistryOxidative phosphorylationOxidative stressBiophysicsCancer researchBiologyCancerMedicineInternal medicineRadiation therapyEnzymeTumor cellsOrganic chemistryGeneticsNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisCancer, Stress, Anesthesia, and Immune Response