Electrochemical Oxidative C–H Amination through a Ritter-Type Reaction
Yiwen Xu, Qiang Li, Runyou Ye, Buyi Xu, Xiangge Zhou
Abstract
an electrochemical Ritter-type reaction is developed. The reaction demonstrates simpler and milder reaction conditions over the existing methods without extra mediator. Moderate to excellent yields up to 94% of the desired amide products were obtained with a broad substrate scope. The removal of the Ac group by a simple step can afford NH-free benzylic amines, providing a suitable approach for the late-stage functionalization of bioactive molecules.
Topics & Concepts
AminationRitter reactionOxidative phosphorylationElectrochemistryChemistryOrganic chemistryElectrodeBiochemistryCatalysisPhysical chemistrySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsRadical Photochemical Reactions