Diethylzinc-Mediated Radical 1,2-Addition of Alkenes and Alkynes
Xin Li, Songtao He, Qiuling Song
Abstract
A novel diethylzinc-mediated radical 1,2-addition of perfluoroalkyl iodides to unactivated alkenes and alkynes is presented, which demonstrates a novel way to generate an ethyl difluoroacetate radical. This method is highly efficient and gives full conversions of the substrates, high yields of the products, and negligible byproducts and requires no column chromatography purifications. The mild conditions enable this protocol to exhibit excellent functional group compatibility.
Topics & Concepts
DiethylzincChemistryCompatibility (geochemistry)Functional groupOrganic chemistryCombinatorial chemistryCatalysisChemical engineeringEnantioselective synthesisEngineeringPolymerFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods