Monoclonal Antibodies against Cell Wall Chitooligomers as Accessory Tools for the Control of Cryptococcosis
Alexandre Bezerra Conde Figueiredo, Fernanda L. Fonseca, Diogo Kuczera, Fernando de Paiva Conte, Marcia Arissawa, Marcio L. Rodrigues
Abstract
tests showed that the chitooligomer MAbs increased the fungicidal capacity of amphotericin B against Cryptococcus neoformans. The chitooligomer-binding MAbs interfered with two essential properties related to cryptococcal pathogenesis: biofilm formation and melanin production. In a murine model of C. neoformans infection, the combined administration of the chitooligomer-binding MAb and subinhibitory doses of amphotericin B promoted disease control. The data obtained in this study support the hypothesis that chitooligomer antibodies have great potential as accessory tools in the control of cryptococcosis.
Topics & Concepts
Monoclonal antibodyCryptococcosisAmphotericin BCryptococcus neoformansIsotypeMicrobiologyAntibodyBiologyCryptococcusImmunologyMonoclonalChitinCell wallAntifungalMycosisVirologyCellFungal Infections and StudiesNail Diseases and TreatmentsInfectious Diseases and Mycology