<i>Petasites japonicus</i> leaf extract inhibits Alzheimer's-like pathology through suppression of neuroinflammation
Hyeyoon Eo, Seung-Min Lee, Seong Hye Kim, In Gyoung Ju, Eugene Huh, Jeongin Lim, Sangsu Park, Myung Sook Oh
Abstract
LPS treatment. Similarly, KP-1 administration protected mice from AβO-induced memory impairment scored by Y-maze and novel object recognition test (NORT). Moreover, KP-1 administration suppressed AβO-induced microglial cell activation measured by counting the number of ionized calcium binding adaptor molecule 1 (Iba-1)-positive cells in both the cortex and hippocampal dentate gyrus and measuring the mRNA expression of TNFα, IL-1β and IL-6. Furthermore, AβO-induced synaptotoxicity was prevented by KP-1 administration which is in line with behavioral changes. Collectively, these findings suggest that KP-1 could be a potential functional food for protection against neuroinflammation, and prevents or delays the progression of AD.