Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons
Pearl P.Y. Lie, Dun‐Sheng Yang, Philip Stavrides, Chris N. Goulbourne, Ping Chen Jue-Ru Zheng, Panaiyur S. Mohan, Anne M. Cataldo, Ralph A. Nixon
Abstract
endosomes/amphisomes, not lysosomes. Restricted lysosome entry into axons explains the unique lysosome distribution in neurons and their vulnerability toward neuritic dystrophy in disease.
Topics & Concepts
LAMP1EndosomeCell biologyLysosomeAxoplasmic transportVacuoleBiologyAutophagyGolgi apparatusOrganelleAxonCytoplasmIntracellularBiochemistryApoptosisEndoplasmic reticulumEnzymeAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolismCellular transport and secretion