Assembly of 5‐Aminoimidazoles via Palladium‐Catalysed Double Isocyanide Insertion Reaction
Xu Wang, Jinping Fu, Jia‐Hui Mo, Yuhong Tian, Chun‐You Liu, Haitao Tang, Zijun Sun, Ying‐Ming Pan
Abstract
Abstract A palladium‐catalysed tandem cyclisation reaction of amidoximes, isocyanides and amines to produce 5‐aminoimidazoles was developed. Various 5‐aminoimidazoles were prepared in good to excellent yields under mild conditions. This elegant domino process involves the effective cleavage of the N−O bond and the formation of new C−C and C−N bonds in a single operation. magnified image
Topics & Concepts
ChemistryPalladiumIsocyanideDominoCleavage (geology)TandemCascade reactionBond cleavagePhotochemistryPolymer chemistryCombinatorial chemistryStereochemistryCatalysisOrganic chemistryComposite materialFracture (geology)Materials scienceGeotechnical engineeringEngineeringCatalytic C–H Functionalization MethodsSynthesis and Biological EvaluationSynthesis and Catalytic Reactions