The Response of Macrophages in Sepsis-Induced Acute Kidney Injury
Jiawei He, Shen Zhao, Meili Duan
Abstract
Sepsis-induced acute kidney injury (SAKI) is common in critically ill patients and often leads to poor prognosis. At present, the pathogenesis of SAKI has not been fully clarified, and there is no effective treatment. Macrophages are immune cells that play an important role in the pathogenesis of SAKI. The phenotype and role of macrophages can vary from early to later stages of SAKI. Elucidating the role of macrophages in SAKI will be beneficial to its diagnosis and treatment. This article reviews past studies describing the role of macrophages in SAKI, with the aim of identifying novel therapeutic targets.
Topics & Concepts
MedicinePathogenesisSepsisAcute kidney injuryMacrophageImmune systemKidneyPhenotypeHost responseImmunologyInflammationInternal medicineIn vitroBiologyGeneBiochemistryAcute Kidney Injury ResearchSepsis Diagnosis and TreatmentThermal Regulation in Medicine