Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
Tasleem Arif, Jiajing Qiu, Hossein Khademian, Anusree Lohithakshan, Anagha Menon, Vijay Menon, Mary Slavinsky, Maxime Batignes, Lin Miao, Robert Sebra, Kristin G. Beaumont, Deanna L. Benson, Nikolaos Tzavaras, Mickaël Ménager, Saghi Ghaffari
Topics & Concepts
BiologyHaematopoiesisCell biologyStem cellMyeloidLysosomeEx vivoTranscriptomeImmune systemHematopoietic stem cellEpigeneticsHomeostasisImmunologyIn vivoStromal cellBone marrowPhenotypeInflammationAutophagyFunction (biology)Regeneration (biology)ATPaseCancer researchMediatorMyeloid cellsAdult stem cellMesenchymal stem cellGene silencingMitochondrionDownregulation and upregulationCD34interferon and immune responsesCell death mechanisms and regulationAutophagy in Disease and Therapy