Improving antibody-based therapies by chemical engineering of antibodies with multimeric cell-penetrating peptides for elevated intracellular delivery
Max Sauter, Matthias Strieker, Christian Kleist, Artjom Wischnjow, Volker Daniel, Annette Altmann, Uwe Haberkorn, Walter Mier
Topics & Concepts
InternalizationCytotoxicityMonoclonal antibodyAntibodyChemistryAntibody-drug conjugateCytotoxic T cellConjugateIntracellularDrug deliveryTrastuzumabAntigenCellBiochemistryImmunologyCancerBiologyIn vitroOrganic chemistryGeneticsMathematicsMathematical analysisBreast cancerRNA Interference and Gene DeliveryMonoclonal and Polyclonal Antibodies ResearchCAR-T cell therapy research